Appendix A

References

Akil, H., and E. J. Nestler. 2023. The neurobiology of stress: Vulnerability, resilience, and major depression. Proceedings of the National Academy of Sciences 120(49):e2312662120.

Aoued, H. S., S. Sannigrahi, N. Doshi, F. G. Morrison, H. Linsenbaum, S. C. Hunter, H. Walum, J. Baman, B. Yao, P. Jin, K. J. Ressler, and B. G. Dias. 2019. Reversing behavioral, neuroanatomical, and germline influences of intergenerational stress. Biological Psychiatry 85(3):248–256.

Aurbach, E. L., E. G. Inui, C. A. Turner, M. H. Hagenauer, K. E. Prater, J. Z. Li, D. Absher, N. Shah, P. Blandino, Jr., W. E. Bunney, R. M. Myers, J. D. Barchas, A. F. Schatzberg, S. J. Watson, Jr., and H. Akil. 2015. Fibroblast growth factor 9 is a novel modulator of negative affect. Proceedings of the National Academy of Sciences 112(38):11953–11958.

Baratta, M. V., N. R. Leslie, I. P. Fallon, S. D. Dolzani, L. E. Chun, A. M. Tamalunas, L. R. Watkins, and S. F. Maier. 2018. Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females. European Journal of Neuroscience 47(8):959–967.

Bennett, S. N., A. B. Chang, F. D. Rogers, P. Jones, and C. J. Peña. 2024. Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior. Hormones and Behavior 159:105472.

Bick, J., T. Zhu, C. Stamoulis, N. A. Fox, C. Zeanah, and C. A. Nelson. 2015. Effect of early institutionalization and foster care on long-term white matter development: A randomized clinical trial. JAMA Pediatrics 169(3):211–219.

Brady, R. G., C. E. Rogers, T. Prochaska, S. Kaplan, R. E. Lean, T. A. Smyser, J. S. Shimony, G. M. Slavich, B. B. Warner, D. M. Barch, J. L. Luby, and C. D. Smyser. 2022. The effects of prenatal exposure to neighborhood crime on neonatal functional connectivity. Biological Psychiatry 92(2):139–148.

Bremner, J. D., N. Z. Gurel, Y. Jiao, M. T. Wittbrodt, O. M. Levantsevych, M. Huang, H. Jung, M. H. Shandhi, J. Beckwith, I. Herring, M. H. Rapaport, N. Murrah, E. Driggers, Y. A. Ko, M. L. Alkhalaf, M. Soudan, J. Song, B. S. Ku, L. Shallenberger, A. N. Hankus, J. A. Nye, J. Park, V. Vaccarino, A. J. Shah, O. T. Inan, and B. D. Pearce. 2020. Transcutaneous vagal nerve stimulation blocks stress-induced activation of interleukin-6 and interferon-gamma in posttraumatic stress disorder: A double-blind, randomized, sham-controlled trial. Brain, Behavior, and Immunity—Health 9:100138.

Brody, G.H., T. Yu, Y. F. Chen, S. M. Kogan, G. W. Evans, S. R. Beach, M. Windle, R. L. Simons, M. Gerrard, F. X. Gibbons, and R. A. Philibert. 2013. Cumulative socioeconomic status risk, allostatic load, and adjustment: A prospective latent profile analysis with contextual and genetic protective factors. Developmental Psychology 49(5):913–927.

California First 5. 2025. What We Do. https://www.ccfc.ca.gov/whatwedo/index.html (accessed June 4, 2025).

Cameron, J. L., K. L. Eagleson, N. A. Fox, T. K. Hensch, and P. Levitt. 2017. Social origins of developmental risk for mental and physical illness. Journal of Neuroscience 37(45):10783–10791.

Campbell-Sills, L., S. B. Norman, M. G. Craske, G. Sullivan, A. J. Lang, D. A. Chavira, A. Bystritsky, C. Sherbourne, P. Roy-Byrne, and M. B. Stein. 2009. Validation of a brief measure of anxiety-related severity and impairment: The Overall Anxiety Severity and Impairment Scale (OASIS). Journal of Affective Disorders 112(1–3):92–101.

Cardenas, S. I., Y. Waizman, V. Truong, P. Sellery, S. A. Stoycos, F. C. Yeh, V. Rajagopalan, and D. E. Saxbe. 2024. White matter microstructure organization across the transition to fatherhood. Developmental Cognitive Neuroscience 67:101374.

Carmona, S. 2024. Neuromaternal: ¿Qué Le Pasa a Mi Cerebro Durante El Embarazo Y La Maternidad? PRH Grupo Editorial.

Chino, M., and L. Debruyn. 2006. Building true capacity: Indigenous models for Indigenous communities. American Journal of Public Health 96(4):596–599.

Conger, R. D., K. J. Conger, G. H. Elder, Jr., F. O. Lorenz, R. L. Simons, and L. B. Whitbeck. 1992. A family process model of economic hardship and adjustment of early adolescent boys. Child Development 63(3):526–541.

COVID-19 Mental Disorders Collaborators. 2021. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet 398(10312):1700–1712.

Del Giudice, M., B. J. Ellis, and E. A. Shirtcliff. 2011. The Adaptive Calibration Model of Stress Responsivity. Neuroscience and Biobehavioral Reviews 35(7):1562–1592.

Dias, B. G., and K. J. Ressler. 2014. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience 17(1):89–96.

Diaz-Gutierrez, J., M. A. Martinez-Gonzalez, A. Alonso, E. Toledo, J. Salas-Salvado, J. V. Sorli, E. Ros, M. Fito, R. Estruch, F. Aros, M. Fiol, J. Lapetra, E. Gomez-Gracia, L. Serra-Majem, X. Pinto, O. Portoles, N. Babio, O. Castaner, and M. Ruiz-Canela. 2023. American Heart Association’s Life Simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort. Nutrition, Metabolism and Cardiovascular Diseases 33(6):1144–1148.

Evans, S. J., P. V. Choudary, C. R. Neal, J. Z. Li, M. P. Vawter, H. Tomita, J. F. Lopez, R. C. Thompson, F. Meng, J. D. Stead, D. M. Walsh, R. M. Myers, W. E. Bunney, S. J. Watson, E. G. Jones, and H. Akil. 2004. Dysregulation of the fibroblast growth factor system in major depression. Proceedings of the National Academy of Sciences 101(43):15506–15511.

Felitti, V. J., R. F. Anda, D. Nordenberg, D. F. Williamson, A. M. Spitz, V. Edwards, and J. S. Marks. 1998. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine 14(4):245–258.

Fernandes, G., M. Fernandes, N. Vaidya, P. De Souza, E. Plotnikova, R. Geddes, B. Holla, E. Sharma, V. Benegal, and V. Choudhry. 2021. Prevalence of child maltreatment in India and its association with gender, urbanisation and policy: A rapid review and metaanalysis protocol. BMJ Open 11(8):e044983.

Galley, J. D., M. K. King, T. A. Rajasekera, A. Batabyal, S. T. Woodke, and T. L. Gur. 2024. Gestational administration of bifidobacterium dentium results in intergenerational modulation of inflammatory, metabolic, and social behavior. Brain, Behavior, and Immunity—Health 122:44–57.

Galley, J. D., L. Mashburn-Warren, L. C. Blalock, C. L. Lauber, J. E. Carroll, K. M. Ross, C. Hobel, M. Coussons-Read, C. Dunkel Schetter, and T. L. Gur. 2023. Maternal anxiety, depression and stress affects offspring gut microbiome diversity and bifidobacterial abundances. Brain, Behavior, and Immunity—Health 107:253–264.

Gard, A. M., J. Brooks-Gunn, S. S. McLanahan, C. Mitchell, C. S. Monk, and L. W. Hyde. 2022a. Deadly gun violence, neighborhood collective efficacy, and adolescent neurobehavioral outcomes. PNAS Nexus 1(3):pgac061.

Gard, A. M., T. C. Hein, C. Mitchell, J. Brooks-Gunn, S. S. McLanahan, C. S. Monk, and L. W. Hyde. 2022b. Prospective longitudinal associations between harsh parenting and corticolimbic function during adolescence. Development and Psychopathology 34(3):981–996.

Gard, A. M., R. Waller, D. S. Shaw, E. E. Forbes, A. R. Hariri, and L. W. Hyde. 2017. The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2(7):582–590.

Geiger, L. T., J. R. Balouek, M. R. Barrett, J. M. Thompson, L. Z. Fang, L. A. Farrelly, A. S. Chen, M. Tang, S. N. Bennett, B. A. Garcia, I. Maze, M. C. Creed, and C. J. Peña. 2025. Early-life stress alters chromatin modifications in VTA to prime stress sensitivity. bioRxiv.

Gillespie, M. L., A. Sharma, T. G. M. Van Erp, M. Ernst, V. M. Murry, and U. Rao. 2020. Functional connectivity during reward-seeking in adolescents enrolled in a riskreduction intervention. Society of Biological Psychiatry Annual Meeting.

Gueorguieva, R., A. M. Chekroud, and J. H. Krystal. 2017. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: An individual patient-level data meta-analysis. Lancet Psychiatry 4(3):230–237.

Gueorguieva, R., C. Mallinckrodt, and J. H. Krystal. 2011. Trajectories of depression severity in clinical trials of duloxetine: Insights into antidepressant and placebo responses. Archives of General Psychiatry 68(12):1227–1237.

Gumusoglu, S. B. 2024. The role of the placenta-brain axis in psychoneuroimmune programming. Brain, Behavior, and Immunity—Health 36:100735.

Gur, T. L., A. V. Palkar, T. Rajasekera, J. Allen, A. Niraula, J. Godbout, and M. T. Bailey. 2019. Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring. Behavioral Brain Research 359:886–894.

Gur, T. L., L. Shay, A. V. Palkar, S. Fisher, V. A. Varaljay, S. Dowd, and M. T. Bailey. 2017. Prenatal stress affects placental cytokines and neurotrophins, commensal microbes, and anxiety-like behavior in adult female offspring. Brain, Behavior, and Immunity—Health 64:50–58.

Herry, C., S. Ciocchi, V. Senn, L. Demmou, C. Muller, and A. Lüthi. 2008. Switching on and off fear by distinct neuronal circuits. Nature 454(7204):600–606.

Hiller, R. M., S. Lehmann, S. J. Lewis, H. Minnis, K. H. Shelton, M. Tarren-Sweeney, and H. N. Taussig. 2023. Accommodating complexity: The need for evidence-informed mental health assessments for children in out-of-home care. Journal of the American Academy of Child and Adolescent Psychiatry 62(1):12–18.

Ho, T. C., and L. S. King. 2021. Mechanisms of neuroplasticity linking early adversity to depression: Developmental considerations. Translational Psychiatry 11(1):517.

Hoekzema, E., E. Barba-Muller, C. Pozzobon, M. Picado, F. Lucco, D. Garcia-Garcia, J. C. Soliva, A. Tobena, M. Desco, E. A. Crone, A. Ballesteros, S. Carmona, and O. Vilarroya. 2017. Pregnancy leads to long-lasting changes in human brain structure. Nature Neuroscience 20(2):287–296.

Hyde, L. W., A. M. Gard, R. C. Tomlinson, G. L. Suarez and H. B. Westerman. 2022. Parents, neighborhoods, and the developing brain. Child Development Perspectives 16:148-156.

Hyde, L. W., R. Waller, C. J. Trentacosta, D. S. Shaw, J. M. Neiderhiser, J. M. Ganiban, D. Reiss, and L. D. Leve. 2016. Heritable and nonheritable pathways to early callousunemotional behaviors. American Journal of Psychiatry 173(9):903–910.

Jones, S. V., L. Stanek-Rattiner, M. Davis, and K. J. Ressler. 2007. Differential regional expression of brain-derived neurotrophic factor following olfactory fear learning. Learning and Memory 14(12):816–820.

Jovanovic, T., A. Smith, A. Kamkwalala, J. Poole, T. Samples, S. D. Norrholm, K. J. Ressler, and B. Bradley. 2011. Physiological markers of anxiety are increased in children of abused mothers. Journal of Child Psychology and Psychiatry and Allied Disciplines, 52(8):844–852.

Katrinli, S., A. X. Maihofer, A. H. Wani, J. R. Pfeiffer, E. Ketema, A. Ratanatharathorn, D. G. Baker, M. P. Boks, E. Geuze, R. C. Kessler, V. B. Risbrough, B. P. F. Rutten, M. B. Stein, R. J. Ursano, E. Vermetten, M. W. Logue, C. M. Nievergelt, A. K. Smith, and M. Uddin. 2022. Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress. Molecular Psychiatry 27(3):1720–1728.

Kaufman, J., J. L. Montalvo-Ortiz, H. Holbrook, K. O’Loughlin, C. Orr, C. Kearney, B. Z. Yang, T. Wang, H. Zhao, R. Althoff, H. Garavan, J. Gelernter, and J. Hudziak. 2018. Adverse childhood experiences, epigenetic measures, and obesity in youth. Journal of Pediatrics 202:150–156.

Kee, M. Z. L., A. Cremaschi, M. De Iorio, H. Chen, T. Montreuil, T. V. Nguyen, S. M. Cote, K. J. O’Donnell, G. F. Giesbrecht, N. Letourneau, S. Y. Chan, and M. J. Meaney. 2023. Perinatal trajectories of maternal depressive symptoms in prospective, community-based cohorts across 3 continents. JAMA Network Open 6(10):e2339942.

Kessing, L. V., L. Sondergard, K. Kvist, and P. K. Andersen. 2005. Suicide risk in patients treated with lithium. Archives of General Psychiatry 62(8):860–866.

Kochanek, K. D., S. L. Murphy, J. Xu, and E. Arias. 2022. Mortality in the United States. National Center for Health Statistics.

Kramer, P. D. 1997. Listening to Prozac: The Landmark Book About Antidepressants and the Remaking of the Self. Penguin Life.

Krishnan, V., M. H. Han, D. L. Graham, O. Berton, W. Renthal, S. J. Russo, Q. Laplant, A. Graham, M. Lutter, D. C. Lagace, S. Ghose, R. Reister, P. Tannous, T. A. Green, R. L. Neve, S. Chakravarty, A. Kumar, A. J. Eisch, D. W. Self, F. S. Lee, C. A. Tamminga, D. C. Cooper, H. K. Gershenfeld, and E. J. Nestler. 2007. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131(2):391–404.

Lei, M. K., M. T. Berg, R. L. Simons, and S. R. H. Beach. 2022. Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults. Social Science and Medicine 293:114654.

Leverett, S. D., R. G. Brady, U. A. Tooley, R. E. Lean, R. Tillman, J. Wilson, M. Ruscitti, R. L. Triplett, D. Alexopoulos, E. D. Gerstein, T. A. Smyser, B. Warner, J. L. Luby, C. D. Smyser, C. E. Rogers, and D. M. Barch. 2025. Associations between parenting and cognitive and language abilities at 2 years of age depend on prenatal exposure to disadvantage. Journal of Pediatrics 276:114289.

Lewitzka, U., E. Severus, R. Bauer, P. Ritter, B. Muller-Oerlinghausen, and M. Bauer. 2015. The suicide prevention effect of lithium: More than 20 years of evidence—A narrative review. International Journal of Bipolar Disorders 3(1):32.

Li, L., R. Durand-de Cuttoli, A. V. Aubry, C. J. Burnett, F. Cathomas, L. F. Parise, K. L. Chan, C. Morel, C. Yuan, Y. Shimo, H. Y. Lin, J. Wang, and S. J. Russo. 2023. Social trauma engages lateral septum circuitry to occlude social reward. Nature 613(7945):696–703.

Luby, J. L., M. P. Herzberg, C. Hoyniak, R. Tillman, R. E. Lean, R. Brady, R. Triplett, D. Alexopoulos, D. Loseille, T. Smyser, C. E. Rogers, B. Warner, C. D. Smyser, and D. M. Barch. 2024. Basic environmental supports for positive brain and cognitive development in the first year of life. JAMA Pediatrics 178(5):465–472.

Lutz, P. E., A. Tanti, A. Gasecka, S. Barnett-Burns, J. J. Kim, Y. Zhou, G. G. Chen, M. Wakid, M. Shaw, D. Almeida, M. A. Chay, J. Yang, V. Lariviere, M. N. M’Boutchou, L. C. van Kempen, V. Yerko, J. Prud’homme, M. A. Davoli, K. Vaillancourt, J. F. Theroux, A. Bramoulle, T. Y. Zhang, M. J. Meaney, C. Ernst, D. Cote, N. Mechawar, and G. Turecki. 2017. Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: Convergent epigenetic, transcriptional, and morphological evidence. American Journal of Psychiatry 174(12):1185–1194.

Maier, S. F., and L. R. Watkins. 2005. Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neuroscience and Biobehavioral Reviews 29(4–5):829–841.

Makino, Y., N. W. Hodgson, E. Doenier, A. V. Serbin, K. Osada, P. Artoni, M. Dickey, B. Sullivan, A. Potter-Dickey, J. Komanchuk, B. Sekhon, N. Letourneau, N. D. Ryan, J. Trauth, J. L. Cameron, and T. K. Hensch. 2024. Sleep-sensitive dopamine receptor expression in male mice underlies attention deficits after a critical period of early adversity. Science Translational Medicine 16(768):eadh9763.

Martinez-Garcia, M., M. Paternina-Die, S. I. Cardenas, O. Vilarroya, M. Desco, S. Carmona, and D. E. Saxbe. 2023. First-time fathers show longitudinal gray matter cortical volume reductions: Evidence from two international samples. Cerebral Cortex 33(7):4156–4163.

McEwen, B. S., and H. Akil. 2020. Revisiting the stress concept: Implications for affective disorders. Journal of Neuroscience 40(1):12–21.

Menard, C., and S. J. Russo. 2018. Non-invasive chemogenetics. Nature Biomedical Engineering 2(7):467–468.

Merrick, M.T., D. C. Ford, K. A. Ports, A. S. Guinn, J. Chen, J. Klevens, M. Metzler, C. M. Jones, T. R. Simon, V. M. Daniel, P. Ottley, and J. A. Mercy. 2019. Vital signs: Estimated proportion of adult health problems attributable to adverse childhood experiences and implications for prevention—25 states, 2015–2017. MMWR. Morbidity and Mortality Weekly Report 68(44):999–1005.

Miller, G. E., G. H. Brody, T. Yu, and E. Chen. 2014. A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth. Proceedings of the National Academy of Sciences 111(31):11287–11292.

Miller-Graff, L. E. 2022. The multidimensional taxonomy of individual resilience. Trauma, Violence, and Abuse 23(2):660–675.

Minnis, H. 2013. Maltreatment-associated psychiatric problems: An example of environmentally triggered essence? Scientific World Journal 2013:148468.

Minnis, H., A.-L. van Harmelen, R. Gajwani, J. Rizeq, E. Combet, R. M. Reynolds, C. Gillberg, M. Henderson, F. K. Ho, V. Mondelli, J. Pell, J. Smith, and P. G. Shiels. 2024. The bio-exposome: Intracellular processes, stress physiology and the environment. Nature Mental Health 2:132–140.

Moazzami, K., M. T. Wittbrodt, M. Alkhalaf, B. B. Lima, J. A. Nye, P. K. Mehta, A. A. Quyyumi, V. Vaccarino, J. D. Bremner, and A. J. Shah. 2020. Association between mental stress-induced inferior frontal cortex activation and angina in coronary artery disease. Circulation: Cardiovascular Imaging 13(8):e010710.

Montalvo-Ortiz, J. L., J. Gelernter, Z. Cheng, M. J. Girgenti, K. Xu, X. Zhang, S. Gopalan, H. Zhou, R. S. Duman, S. M. Southwick, J. H. Krystal, G. Traumatic Stress Brain Research Study, and R. H. Pietrzak. 2022. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry 12(1):65.

Morgan, C. A., III, S. Wang, S. M. Southwick, A. Rasmusson, G. Hazlett, R. L. Hauger, and D. S. Charney. 2000. Plasma neuropeptide-Y concentrations in humans exposed to military survival training. Biological Psychiatry 47(10):902–909.

Morrison, F. G., B. G. Dias, and K. J. Ressler. 2015. Extinction reverses olfactory fearconditioned increases in neuron number and glomerular size. Proceedings of the National Academy of Sciences 112(41):12846–12851.

Murry, V. M., J. M. Nyanamba, R. Hanebutt, M. Debreaux, K. A. B. Gastineau, A. K. B. Goodwin, and L. Narisetti. 2023. Critical examination of resilience and resistance in African American families: Adaptive capacities to navigate toxic oppressive upstream waters. Development and Psychopathology 35(5):2113–2131.

Navarrete, J., K. N. Schneider, B. M. Smith, N. L. Goodwin, Y. Y. Zhang, A. S. Salazar, Y. E. Gonzalez, P. Anumolu, E. Gross, V. S. Tsai, M. Heshmati, and S. A. Golden. 2024. Individual differences in volitional social self-administration and motivation in male and female mice following social stress. Biological Psychiatry 96(4):309–321.

Nestler, E. J., and S. J. Russo. 2024. Neurobiological basis of stress resilience. Neuron 112(12):1911–1929.

Nievergelt, C. M., A. X. Maihofer, E. G. Atkinson, C. Y. Chen, K. W. Choi, J. R. I. Coleman, N. P. Daskalakis, L. E. Duncan, R. Polimanti, C. Aaronson, A. B. Amstadter, S. B. Andersen, O. A. Andreassen, P. A. Arbisi, A. E. Ashley-Koch, S. B. Austin, E. Avdibegovic, D. Babic, S. A. Bacanu, D. G. Baker, A. Batzler, J. C. Beckham, S. Belangero, C. Benjet, C. Bergner, L. M. Bierer, J. M. Biernacka, L. J. Bierut, J. I. Bisson, M. P. Boks, E. A. Bolger, A. Brandolino, G. Breen, R. A. Bressan, R. A. Bryant, A. C. Bustamante, J. Bybjerg-Grauholm, M. Baekvad-Hansen, A. D. Borglum, S. Borte, L. Cahn, J. R. Calabrese, J. M. Caldas-de-Almeida, C. Chatzinakos, S. Cheema, S. A. P. Clouston, L. Colodro-Conde, B. J. Coombes, C. S. Cruz-Fuentes, A. M. Dale, S. Dalvie, L. K. Davis, J. Deckert, D. L. Delahanty, M. F. Dennis, F. Desarnaud, C. P. DiPietro, S. G. Disner, A. R. Docherty, K. Domschke, G. Dyb, A. D. Kulenovic, H. J. Edenberg, A. Evans, C. Fabbri, N. Fani, L. A. Farrer, A. Feder, N. C. Feeny, J. D. Flory, D. Forbes, C. E. Franz, S. Galea, M. E. Garrett, B. Gelaye, J. Gelernter, E. Geuze, C. F. Gillespie, S. B. Goleva, S. D. Gordon, A. Goci, L. R. Grasser, C. Guindalini, M. Haas, S. Hagenaars, M. A. Hauser, A. C. Heath, S. M. J. Hemmings, V. Hesselbrock, I. B. Hickie, K. Hogan, D. M. Hougaard, H. Huang, L. M. Huckins, K. Hveem, M. Jakovljevic, A. Javanbakht, G. D. Jenkins, J. Johnson, I. Jones, T. Jovanovic, K. I. Karstoft, M. L. Kaufman, J. L. Kennedy, R. C. Kessler, A. Khan, N. A. Kimbrel, A. P. King, N. Koen, R. Kotov, H. R. Kranzler, K. Krebs, W. S. Kremen, P. F. Kuan, B. R. Lawford, L. A. M. Lebois, K. Lehto, D. F. Levey, C. Lewis, I. Liberzon, S. D. Linnstaedt, M. W. Logue, A. Lori, Y. Lu, B. J. Luft, M. K. Lupton, J. J. Luykx, I. Makotkine, J. L. Maples-Keller, S. Marchese, C. Marmar, N. G. Martin, G. A. Martinez-Levy, K. McAloney, A. McFarlane, K. A. McLaughlin, S. A. McLean, S. E. Medland, D. Mehta, J. Meyers, V. Michopoulos, E. A. Mikita, L. Milani, W. Milberg, M. W. Miller, R. A. Morey, C. P. Morris, O. Mors, P. B. Mortensen, M. S. Mufford, E. C. Nelson, M. Nordentoft, S. B. Norman, N. R. Nugent, M. O’Donnell, H. K. Orcutt, P. M. Pan, M. S. Panizzon, G. A. Pathak, E. S. Peters, A. L. Peterson, M. Peverill, R. H. Pietrzak, M. A. Polusny, B. Porjesz, A. Powers, X. J. Qin, A. Ratanatharathorn, V. B. Risbrough, A. L. Roberts, A. O. Rothbaum, B. O. Rothbaum, P. Roy-Byrne, K. J. Ruggiero, A. Rung, H. Runz, B. P. F. Rutten, S. S. de Viteri, G. A. Salum, L. Sampson, S. E. Sanchez, M. Santoro, C. Seah, S. Seedat, J. S. Seng, A. Shabalin, C. M. Sheerin, D. Silove, A. K. Smith, J. W. Smoller, S. R. Sponheim, D. J. Stein, S. Stensland, J. S. Stevens, J. A. Sumner, M. H. Teicher, W. K. Thompson, A. K. Tiwari, E. Trapido, M. Uddin, R. J. Ursano, U. Valdimarsdottir, M. Van Hooff, E. Vermetten, C. H. Vinkers, J. Voisey, Y. Wang, Z. Wang, M. Waszczuk, H. Weber, F. R. Wendt, T. Werge, M. A. Williams, D. E. Williamson, B. S. Winsvold, S. Winternitz, C. Wolf, E. J. Wolf, Y. Xia, Y. Xiong, R. Yehuda, K. A. Young, R. M. Young, C. C. Zai, G. C. Zai, M. Zervas, H. Zhao, L. A. Zoellner, J. A. Zwart, T. deRoon-Cassini, S. J. H. van Rooij, L. L. van den Heuvel, A. Study, T. Estonian Biobank Research, I. FinnGen, H. A.-I. Psychiatry, M. B. Stein, K. J. Ressler, and K. C. Koenen. 2024. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics 56(5):792–808.

Nunez-Rios, D. L., J. J. Martinez-Magana, S. T. Nagamatsu, D. E. Andrade-Brito, D. A. Forero, C. A. Orozco-Castano, and J. L. Montalvo-Ortiz. 2022. Central and peripheral immune dysregulation in posttraumatic stress disorder: Convergent multi-omics evidence. Biomedicines 10(5):1107.

Office of the California Surgeon General. 2025. Adverse Childhood Experiences (ACEs) and Toxic Stress. https://osg.ca.gov/aces-toxic-stress/ (accessed June 4, 2025).

Parade, S. H., L. Huffhines, T. E. Daniels, L. R. Stroud, N. R. Nugent, and A. R. Tyrka. 2021. A systematic review of childhood maltreatment and DNA methylation: Candidate gene and epigenome-wide approaches. Translational Psychiatry 11(1):134.

Pataskar, A., J. Jung, P. Smialowski, F. Noack, F. Calegari, T. Straub, and V. K. Tiwari. 2016. NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. EMBO Journal 35(1):24–45.

Peña, C. J. 2025. Early-life stress sensitizes response to future stress: Evidence and mechanisms. Neurobiology of Stress 35:100716.

Peña, C. J., H. G. Kronman, D. M. Walker, H. M. Cates, R. C. Bagot, I. Purushothaman, O. Issler, Y. E. Loh, T. Leong, D. D. Kiraly, E. Goodman, R. L. Neve, L. Shen, and E. J. Nestler. 2017. Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2. Science 356(6343):1185–1188.

Peña, C. J., M. Smith, A. Ramakrishnan, H. M. Cates, R. C. Bagot, H. G. Kronman, B. Patel, A. B. Chang, I. Purushothaman, J. Dudley, H. Morishita, L. Shen, and E. J. Nestler. 2019. Early life stress alters transcriptomic patterning across reward circuitry in male and female mice. Nature Communications 10(1):5098.

Peterson, C., M. V. Aslam, P. H. Niolon, S. Bacon, M. A. Bellis, J. A. Mercy, and C. Florence. 2023. Economic burden of health conditions associated with adverse childhood experiences among US adults. JAMA Network Open 6(12):e2346323.

Putnam, K. T., W. W. Harris, and F. W. Putnam. 2013. Synergistic childhood adversities and complex adult psychopathology. Journal of Traumatic Stress 26(4):435–442.

Rajasekera, T. A., J. D. Galley, A. R. Mackos, H. J. Chen, J. G. Mitchell, J. J. Kleinman, P. Cappelucci, L. Mashburn-Warren, C. L. Lauber, M. T. Bailey, and B. L. Worly. 2024. Stress and depression-associated shifts in gut microbiota: A pilot study of human pregnancy. Brain, Behavior, and Immunity—Health 36:100730.

Rakers, F., S. Rupprecht, M. Dreiling, C. Bergmeier, O. W. Witte, and M. Schwab. 2017. Transfer of maternal psychosocial stress to the fetus. Neuroscience and Biobehavioral Reviews 117:185-197.

Reinert, M., D. Fritze, and T. Nguyen. 2024. The State of Mental Health in America, 2024. Mental Health America.

Ressler, K. J., B. O. Rothbaum, L. Tannenbaum, P. Anderson, K. Graap, E. Zimand, L. Hodges, and M. Davis. 2004. Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear. Archives of General Psychiatry 61(11):1136–1144.

Rutter, M. 1985. Resilience in the face of adversity: Protective factors and resistance to psychiatric disorder. The British Journal of Psychiatry 147(6):598–611.

Saad, L. 2025. Pandemic’s Effects Linger in Americans’ Health Ratings. Gallup.

Sanders, A. F. P., B. Tirado, N. A. Seider, R. L. Triplett, R. E. Lean, J. J. Neil, J. P. Miller, R. Tillman, T. A. Smyser, D. M. Barch, J. L. Luby, C. E. Rogers, C. D. Smyser, B. B. Warner, E. Chen, and G. E. Miller. 2024. Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: Associations with neonatal white matter microstructure. Translational Psychiatry 14(1):72.

Sarai, S. K., H. M. Mekala, and S. Lippmann. 2018. Lithium suicide prevention: A brief review and reminder. Innovations in Clinical Neuroscience 15(11–12):30–32.

Saxbe, D., and M. Martinez-Garcia. 2024. Cortical volume reductions in men transitioning to first-time fatherhood reflect both parenting engagement and mental health risk. Cerebral Cortex 34(4):bhae126.

Sheftall, A. H. 2023. The tragedy of Black youth suicide. Association of American Medical Colleges.

Smith, G. D., and S. Ebrahim. 2003. “Mendelian randomization”: Can genetic epidemiology contribute to understanding environmental determinants of disease? International Journal of Epidemiology 32(1):1–22.

Solmi, M., G. Seitidis, D. Mavridis, C. U. Correll, E. Dragioti, S. Guimond, L. Tuominen, A. Dargel, A. F. Carvalho, M. Fornaro, M. Maes, F. Monaco, M. Song, J. Il Shin, and S. Cortese. 2023. Incidence, prevalence, and global burden of schizophrenia—Data, with critical appraisal, from the global burden of disease (GBD) 2019. Molecular Psychiatry 28(12):5319–5327.

Stenson, A. F., S. J. H. van Rooij, S. E. Carter, A. Powers, and T. Jovanovic. 2021. A legacy of fear: Physiological evidence for intergenerational effects of trauma exposure on fear and safety signal learning among African Americans. Behavioural Brain Research 402:113017.

Suarez, G. L., S. A. Burt, A. M. Gard, J. Burton, D. A. Clark, K. L. Klump, and L. W. Hyde. 2022. The impact of neighborhood disadvantage on amygdala reactivity: Pathways through neighborhood social processes. Developmental Cognitive Neuroscience 54:101061.

Suarez, G. L., S. A. Burt, A. M. Gard, K. L. Klump, and L. W. Hyde. 2024. Exposure to community violence as a mechanism linking neighborhood disadvantage to amygdala reactivity and the protective role of parental nurturance. Developmental Psychology 60(4):595–609.

Taylor, H. A., T. Finkel, Y. Gao, S. W. Ballinger, R. Campo, R. Chen, S. H. Chen, K. Davidson, M. L. Iruela-Arispe, C. Jaquish, N. K. LeBrasseur, M. C. Odden, G. J. Papanicolaou, M. Picard, P. Srinivas, O. Tjurmina, M. Wolz, and Z. S. Galis. 2022. Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop. The FASEB Journal 36(12):e22639.

Taylor, W. W., L. Korobkova, N. Bhinderwala, and B. G. Dias. 2025. Toward understanding and halting legacies of trauma. Biological Psychiatry 98(10):756–766.

Tondo, L., and R. J. Baldessarini. 2024. Prevention of suicidal behavior with lithium treatment in patients with recurrent mood disorders. International Journal of Bipolar Disorders 12(1):6.

Turner, C. A., H. Khalil, V. Murphy-Weinberg, M. H. Hagenauer, L. Gates, Y. Tang, L. Weinberg, R. Grysko, L. Floran-Garduno, T. Dokas, C. Samaniego, Z. Zhao, Y. Fang, S. Sen, J. F. Lopez, S. J. Watson, Jr., and H. Akil. 2023. The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress. Proceedings of the National Academy of Sciences 120(49):e2305779120.

Turner, C. A., S. J. Watson, and H. Akil. 2012. The fibroblast growth factor family: Neuromodulation of affective behavior. Neuron 76(1):160–174.

Vaccarino, V., Z. Almuwaqqat, J. H. Kim, M. Hammadah, A. J. Shah, Y. A. Ko, L. Elon, S. Sullivan, A. Shah, A. Alkhoder, B. B. Lima, B. Pearce, L. Ward, M. Kutner, Y. Hu, T. T. Lewis, E. V. Garcia, J. Nye, D. S. Sheps, P. Raggi, J. D. Bremner, and A. A. Quyyumi. 2021. Association of mental stress-induced myocardial ischemia with cardiovascular events in patients with coronary heart disease. JAMA 326(18):1818–1828.

Vaccarino, V., J. Goldberg, C. Rooks, A. J. Shah, E. Veledar, T. L. Faber, J. R. Votaw, C. W. Forsberg, and J. D. Bremner. 2013. Post-traumatic stress disorder and incidence of coronary heart disease: A twin study. Journal of the American College of Cardiology 62(11):970–978.

Vaccarino, V., A. J. Shah, V. Moncayo, J. Nye, M. Piccinelli, Y. A. Ko, X. Ma, N. Murrah, L. Shallenberger, E. Driggers, O. M. Levantsevych, M. Hammadah, B. B. Lima, A. Young, W. O’Neal, M. Alkhalaf, A. Haffar, P. Raggi, J. Goldberg, N. L. Smith, E. V. Garcia, A. A. Quyyumi, and J. D. Bremner. 2022. Posttraumatic stress disorder, myocardial perfusion, and myocardial blood flow: A longitudinal twin study. Biological Psychiatry 91(7):615–625.

Verosky, B. G., M. T. Bailey, and T. L. Gur. 2025. The metabolomic mind: Microbial metabolite programming of microglia. Neuroimmunomodulation 32(1):139–149.

Vila-Badia, R., A. Butjosa, N. Del Cacho, C. Serra-Arumi, M. Esteban-Sanjusto, S. Ochoa, and J. Usall. 2021. Types, prevalence and gender differences of childhood trauma in first-episode psychosis. What is the evidence that childhood trauma is related to symptoms and functional outcomes in first episode psychosis? A systematic review. Schizophrenia Research 228:159–179.

Walker, D. L., K. J. Ressler, K. T. Lu, and M. Davis. 2002. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. Journal of Neuroscience 22(6):2343–2351.

Westerman, H. B., G. L. Suarez, L. S. Richmond-Rakerd, R. Nusslock, K. L. Klump, S. A. Burt, and L. W. Hyde. 2024. Exposure to community violence as a mechanism linking neighborhood socioeconomic disadvantage and neural responses to reward. Social Cognitive and Affective Neuroscience 19(1):nsae029.

Wingo, A. P., G. Wrenn, T. Pelletier, A. R. Gutman, B. Bradley, and K. J. Ressler. 2010. Moderating effects of resilience on depression in individuals with a history of childhood abuse or trauma exposure. Journal of Affective Disorders 126(3):411–414.

Wrenn, K., B. Lorenzen, I. Jones, C. Zhou, and D. Aronsky. 2010. Factors affecting stress in emergency medicine residents while working in the ED. Annals of Emergency Medicine 28(8):897–902.

Writing Committee for the ENRICHD Investigators. 2003. Effects of treating depression and low perceived social support on clinical events after myocardial infarction. Journal of the American Medical Association 289:3106-3116.

Xia, F., V. Fascianelli, N. Vishwakarma, F. G. Ghinger, A. Kwon, M. M. Gergues, L. K. Lalani, S. Fusi, and M. A. Kheirbek. 2025. Understanding the neural code of stress to control anhedonia. Nature 637(8046):654–662.

Yeo, B. T., F. M. Krienen, J. Sepulcre, M. R. Sabuncu, D. Lashkari, M. Hollinshead, J. L. Roffman, J. W. Smoller, L. Zöllei. J. R. Polimeni, and B. Fischl. 2011. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. Journal of Neurophysiology 106(3):1125-1165.

Zhang, T. Y., C. L. Keown, X. Wen, J. Li, D. A. Vousden, C. Anacker, U. Bhattacharyya, R. Ryan, J. Diorio, N. O’Toole, J. P. Lerch, E. A. Mukamel, and M. J. Meaney. 2018. Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus. Nature Communications 9(1):298.

Zhu, H., X. Yang, S. Xie, and J. Zhou. 2023. Prevalence of burnout and mental health problems among medical staff during the COVID-19 pandemic: A systematic review and meta-analysis. BMJ Open 13(7):e061945.