This proposal review committee will evaluate submissions received in response to a Request for Proposals for biomolecular simulation time on Anton 3, a supercomputer specially designed and built by D.E. Shaw Research (DESRES). For several years, DESRES has made an Anton system housed at the Pittsburgh Supercomputing Center available to the non-commercial research community. The goal is to facilitate breakthrough research in the study of biomolecular systems by providing a massively parallel system specially designed for molecular dynamics simulations.