In progress
Precision medicine approaches are rapidly transforming neuroscience, driven by advances in genetics, neuroimaging, biomarkers, and data science. These tools enable more refined disease classification, improved diagnosis, and treatments tailored to individual patients across neurological and psychiatric disorders. However, challenges remain in translating these advances into routine research and clinical practice. On March 4–5, the National Academies’ Forum on Neuroscience and Nervous System Disorders, in collaboration with the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health, will host a workshop exploring opportunities, challenges, and strategies for integrating precision medicine into neuroscience research and care.
Description
A planning committee of the National Academies of Sciences, Engineering, and Medicine will host a 1.5-day public workshop to examine opportunities and challenges in applying precision medicine approaches to understanding and treating brain disorders. The workshop will bring together experts and stakeholders from across sectors and disciplines to explore how advances in biology, data science, drug development, and clinical practice are shaping the future of individualized care for neurological and psychiatric conditions.
Invited presentations and discussions may:
- Highlight case examples where precision medicine approaches have informed research, diagnosis, treatment, and disease reclassification in neuroscience.
- Examine emerging tools and technologies (including biomarkers, multi-omics, computational psychiatry, and artificial intelligence) and their applications across neuroscience research and clinical care.
- Consider barriers and opportunities for implementation, including provider education, patient engagement, payer and regulatory models, data privacy, clinical integration, and potential risks.
- Explore models for academia-industry-regulatory collaboration to de-risk precision drug development in neuroscience.
- Explore cross-disease and holistic frameworks, including how precision medicine approaches can address comorbidities and support a broader brain health model.
A planning committee will develop the agenda for the workshop, select and invite speakers and discussants, and moderate the discussions. Following the workshop, a proceedings of the presentations and discussions will be prepared by a designated rapporteur in accordance with institutional guidelines.
Contributors
Committee
Rosa Canet-Avilés
Co-Chair
Gayle Wittenberg
Co-Chair
Linda S. Brady
Member
Laura Bustamante
Member
Brian Fiske
Member
Magali Haas
Member
Julie Harris
Member
Steven E. Hyman
Member
Michael Irizarry
Member
Bruce Korf
Member
Dimitri Krainc
Member
Sponsors
23andMe
Acadia Pharmaceuticals
All of Us Research Program
Alzheimer's Association
American Academy of Nursing
American Brain Coalition
American College of Medical Genetics and Genomics
American College of Neuropsychopharmacology
American Medical Association
American Neurological Association
American Society of Clinical Oncology
American Society of Human Genetics
Amgen Inc
Apricity Health, Inc.
Association for Molecular Pathology
Association of American Medical Colleges
Biogen
BrightFocus Foundation
Burroughs Wellcome Fund
California Institute for Regenerative Medicine
Cohen Veterans Bioscience
College of American Pathologists
Critical Path Institute
Dana Foundation
Department of Veterans Affairs
Eisai
Eli Lilly and Company
FasterCures, Milken Institute
Food and Drug Administration
Foundation for the National Institutes of Health
Gatsby Charitable Foundation
Geisinger Health
Genome Medical
Harmony Biosciences
Health Resources and Services Administration
Huo Family Foundation
Illumina Inc.
Janssen Research & Development, LLC
Johnson & Johnson
Kaiser Permanente
Medable
Merck & Co., Inc.
Michael J. Fox Foundation for Parkinson's Research
Myriad Genetics
National Cancer Institute
National Center for Complementary and Integrative Health
National Eye Institute
National Human Genome Research Institute
National Institute of Environmental Health Sciences
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute of Nursing Research
National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
National Institutes of Health BRAIN Initiative
National Multiple Sclerosis Society
National Science Foundation
National Society of Genetic Counselors, Inc
New England Journal of Medicine
One Mind
Paul G. Allen Frontiers Group
Regeneron Pharmaceuticals
Sanofi
Simons Foundation
The Jackson Laboratory (JAX)
Tufts Center for the Study of Drug Development
University of California, San Francisco
University of Vermont Health Network Medical Group
Staff
Sheena Posey Norris
Lead
Ashley Pitt
Sarah Beachy
Carolyn Shore
Major units and sub-units
Center for Health, People, and Places
Lead
Biomedical and Health Sciences Program Area
Lead
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