The National Academies of Sciences, Engineering, and Medicine will establish an Initiative for Resilient and Enduring Data Infrastructure for Biomedical and Life Sciences Research and Innovation (REDI Initiative) to foster collaborative action toward sustainable, accessible, and usable data infrastructure. Initiative discussions, workstreams, and activities will:

• Promote collective action toward sustainable and purpose-driven data infrastructure for biomedical/life sciences research and innovation;
• Advance attention to and implementation of a lifecycle-based approach to management of biological and biomedical databases from creation to sunsetting;
• Support the field in experimenting with and learning from new approaches to database sustainability, including business models; and
• Strengthen multisector, multi-stakeholder collaborative networks.

The Initiative will address the intersection of the use of databases to advance scientific discovery and innovation, the infrastructure and business models required for sustainability, and the move to enhance data access, interoperability, and sharing. It will serve to align and cross-fertilize efforts, avoid duplication, and magnify results among the many experts, organizations, and networks working to address different aspects of funding, sustainability, sharing, curation, and management of biomedical and life sciences databases and associated tools.